岳倩，博士，讲师。
研究领域：
1. 探索阿尔茨海默症中血脑屏障损伤及神经血管单元细胞病理
2. 探索APOE4阿尔茨海默症中神经血管单元细胞（星形胶质细胞，脑内皮细胞，小胶质细胞）病理机制，以及细胞间通讯机理；
3. 探索中药活性成分基于神经血管单元细胞病理调控，进而治疗阿尔茨海默症的潜能。
主持或参与项目：
1. 国家自然科学基金青年项目，“苦木提取物铁屎米酮通过调控神经血管单元细胞病理治疗APOE4阿尔茨海默症的机制研究”，82404892，30万，2025.01-2027.12，项目负责人。
2. 澳门大学基金：“研发一种综合决策平台通过深度学习及基于四元数变换的策略结合神经影像及临床数据对痴呆症进行早期预测”，MYRG-CRG2022-00010-ICMS，参与。
3. 澳门基金会基金：“利用人工智能模型用于早期监测及干预老年人群体的痴呆症”，FDCT 0015/2019/ASC，全文撰写，参与。
4. 澳门大学基金：“中草药苦木活性提取物在体外星形胶质细胞与脑内皮细胞共培养炎症模型中的抗炎机理研究”，QRCM-IRG2022-017，全文撰写，参与。公开
发表论文：
[1]. Yue, Q. (唯一第一作者), Xinyue Leng, Ningqing Xie, Zaijun Zhang, Deguang Yang*, Maggie Pui Man Hoi*. (2024). Endothelial Dysfunctions in Blood-Brain Barrier Breakdown in Alzheimer’s disease: From mechanisms to potential therapies. CNS Neuroscience&Therapeutics, 30(11), e70079. (影响因子: 5.0, JCR Q1,中科院二区)
[2]. Yue, Q. (唯一第一作者), Shang Li, Huaibin Wan*, Zaijun Zhang*, Maggie Pui Man Hoi*. (2024). Insights into the transcriptomic heterogeneity of brain microvessel endothelial cells in normal ageing and Alzheimer’s disease. Neural Regeneration Research, 21(2), 569-576. (影响因子: 6.7, JCR Q1)
[3]. Yue, Q. (唯一第一作者), Hoi P. (2023) Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer’s disease. Neural Regeneration Research, 18(9):1890-1902. (影响因子: 6.7, JCR Q1，中科院二区，入选2023年9月刊封面文章，ESI热点论文)
[4]. Yue, Q. (唯一第一作者), Xu, Y., Lin, L., & Hoi, P. (2022). Canthin-6-one (CO) from Picrasma quassioides (D. Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption. Phytomedicine, 101, 154108. (影响因子: 8.3, JCR Q1,中科院一区)
[5]. Yue, Q. (唯一第一作者), Zhou, X., Zhang, Z., & Hoi, P. (2022). Murine beta-amyloid (1–42) oligomers disrupt endothelial barrier integrity and VEGFR signaling via activating astrocytes to release deleterious soluble factors. International Journal of Molecular Sciences, 23(3), 1878. (影响因子: 5.6, JCR Q1，中科院二区)
[6]. Chen, Q., Liang, Z., Yue, Q. (第二作者), Wang, X., Siu, S., Hoi, P. & Lee, S. (2022). A neuropeptide Y/F-like polypeptide derived from the transcriptome of Turbinaria peltata suppresses LPS-induced astrocytic inflammation. Journal of Natural Products, 85(6), 1569-1580. (影响因子: 3.3, JCR Q1，中科院二区)
[7]. Liang, Z. R., Lin, C. J., Liu, Y. H., Yue, Q., & Hoi, P. M. (2025). Crocin Inhibited Aβ Generation via Modulating APP Processing, Suppressing Endoplasmic Reticulum Stress and Activating Autophagy in N2a/APP Cells. Chinese Journal of Integrative Medicine, 31(11), 973-981.(影响因子：2.9, JCR Q2)
[8]. Lin, C., Yue, Q. (共同第一作者), Liang, Z., Lee, S., Zhang, Z., & Hoi, P. (2021). Crocin inhibited amyloid-beta (Aβ) generation via promoting non-amyloidogenic APP processing and suppressed ER stress UPR signaling in N2a/APP cells. bioRxiv, 2021-09.
[9]. Yue, Q. (唯一第一作者), & Hoi, P. M. M. (2024). Heterogeneity of brain endothelial cell transcriptome in Alzheimer’s disease brain tissue. Alzheimer's & Dementia, 20, e092105. (会议海报，发表于影响因子：13.0, JCR Q1的Alzheimer’s & Dementia期刊)
[10]. Yue, Q. (唯一第一作者), & Hoi, P. M. M. (2023). Expression patterns of astrocyte mRNA under numerous in vitro disease conditions and its applicability in drug development. Alzheimer's & Dementia, 19, e071911. (会议海报，发表于影响因子：13.0, JCR Q1，中科院一区的Alzheimer’s & Dementia期刊)
[11]. Yue, Q. (唯一第一作者), Hoi, P. (2018) Aβ1‑42 oligomers disrupted bEnd.3 brain endothelial cell junction integrity: a potential in vitro model to study TCM protective compounds for blood–brain barrier in Alzheimer’s pathology. The 4th Global Chinese Symposium and the 8th Symposium for cross-straits, Hong Kong and Macao on free radical biology and medicine. Abstract Book: Chin Med 13 (Suppl 2: A11), 56. (会议论文，(影响因子: 6.1, JCR Q1，中科院二区)
